This study aims to describe the design of innovation learning in the era of industrial revolution 4.0 that can optimize 21^st century skills for elementary school students. The research method used is a qualitative descriptive literature study. Data collection techniques are carried out by studying various references such as proceeding articles, journals, books and other supporting sources. The data that has been obtained is then analyzed by analysis content. The results showed that the design of innovation learning era industrial revolution 4.0 In optimizing the competence of the 21^st century for elementary school students is to consider four important things, namely the characteristics of elementary school students as a generation of the 21^st century; Profile of 21^st century teachers; the characteristics of 21^st century learning itself; and consider active learning models that can develop students' creativity. Characteristics of elementary school students include; fluent in technology, multitasking, active, playing, imagining, singing, and group fun—the appearance of teachers of the 21^st century can be adaptive with the technology, bewitch, creative, and compassionate. Characteristics of 21^st century learning include; integrate ICT, HOTS, 4C, character, and literacy in the learning process. The active learning model is project-based learning and problem-based learning. Furthermore, researchers offered the learning design to be packaged into interactive media using the sac application (Smart App Creator). SAC is one of the applications that can be used to design more interesting and interactive learning. so, it is suitable for elementary school students.