The prevalence of type-II diabetes among Asian country citizens is very high. China, India and Indonesia are listed in the top five country in the world for both prevalence number and deaths. Research showed that the high prevalence was strongly related to socio-economic conditions of those countries. Instant powder drinks are very popular among citizens with lower socio-economic status. Functional drinks with low-carbohydrate content were seen as one of the best alternatives in campaign to decrease the diabetes prevalence number. The objective of the research is to find optimum product formulation of instant powder drinks made from black jelly grass (Mesona palustris BL), stevia leaves (stevia rebaudiana), lemon (citrus lemon) and clove (Syzygium aromaticum). No sugar added at all. The sweetness of the drink will be given by the extract of stevia leaves, a natural sweetener used by villagers. The research was carried out by a mixture design of experiment. The measured response variables are the level of antioxidants, phenol, flavonoid, vitamin C and pH level. The Design Expert software were used to develop the design of experiment and to analyze the result. The results show that the optimum formulation was found in a composition which gives the following parameters: a 201 ppm of total phenol, 72.61 ppm of flavonoid, 59.73% of antioxidant activity, 16.799 mg/mL of vitamin C and 5.05 of pH.