Lean Six Sigma and Industrial 4.0 are two powerful approaches being widely discussed by researchers and practitioners. Even, these methodologies were rooted independently, but both are aiming to gain competitiveness and serve the customer needs. The aim of the lean six sigma  (LSS) philosophy is to achieve the quality levels of 3.4 parts per million defects by reducing the waste and variations in the processes. Industry 4.0 is mainly focusing on the digitalization of manufacturing activities with powerful data analysis methods. There has been limited literature discussing the synergy between Industry 4.0 and LSS. Most LSS tools and techniques are based on traditional statistical techniques and operational tools. The objective is this presentation is to propose how the Industry 4.0 enabling technologies can be exploited as enablers in achieving the Six Sigma Quality Level. The six sigma problem-solving methodology, Define-Measure-Analyse-Improve-Control (DMAIC) is related to the Industry 4.0 enabling technologies. The presentation clarifies how each of the DMAIC phases can benefit from digital technologies. The presentation concludes with proposed agenda for further research