Background: Majority of the major accidents are mostly due to “Human Error” (HE) including those in oil and gas industry either at offshore or onshore worksite. The aim of this research is to develop Knowledge Management (KM) framework and link with Human Error (HE) which can be used to prevent, minimize or reduce major accident among oil and gas industry players in offshore and onshore installations. Objective: Therefore the research is supported by the following objectives (1) To investigate the relationship between the KM factors and HE;  (2) To find out what HE factors might contribute to the major accident; and (3) To develop an integrated framework integrating KM and HE to prevent major accident. A research methodology and literature review about KM and HE in major accident prevention was developed on how KM in HE can prevent major accident in oil and gas installations, what are the most suitable KM types, how effective is KM in offshore installations and what is the best method of sharing the outcome from KM in oil and gas installations. Results: The results, findings and analysis of secondary data will be presented, cross sectional survey questionnaire and the interview data from the view of the Company and Contractors in which is among the primary data of the research. Relevant and related research questions are included in the questionnaire. The results and the conclusions are based on the analysis of feedback from the selected respondents using Statistical Package for Social Science (SPSS) software Conclusion: Possible result of developing KM framework implementation in OSH and integrating HE to prevent major accident in oil and gas installations.