I4.0 can make a positive impact on healthcare by means of digitalization, automation, and evidence-based practices due to their potential. However, integration is still insufficient in Bangladesh because infrastructural needs have not been met, workforce is inadequate, its policies are not strong and awareness is low. This paper proposes a hybrid Model between Interpretive Structural Modeling (ISM) and Partial Least Squares Structural Equation Modeling (PLS-SEM) to assess the Digital readiness Capability. The analysis of a survey of 143 healthcare organizations was examined to test casual relationship and identify interdependencies between the barriers. In the PLS-SEM results, both organizational and technological readiness are significant factors driving the digital readiness status and environmental enablers exert their influence on digital readiness through organization mediation. The combined findings indicate that the key to the successful transformation is the necessity to address such underlying technological and organizational issues. The proposed research will make both theoretical and practical contributions through its provision of a replicable ISM PLS-SEM framework and practical recommendations to be used by healthcare policymakers and administrators in Bangladesh and other developing economies in their endeavors towards the implementation of digital health