Though Quality 4.0 promised a future for enhanced sustainability, and even though it is evident in some micro cases, macro benefits are still shortcoming, as the broader impact Quality 4.0 on sustainability is still missing on energy consumption, inequality, unemployment issues, and the preservation of nature. This motivated the transition and talks around Industry 5.0. This study aims to explore the integration of quality management practices with Industry 5.0’s core features, focusing on human-centric technological advancement and addressing life value threatening challenges. The study follows designs a Quality 5.0 framework by evaluating the impact of Industry 5.0 core features and concepts on quality management practices to ethically enhance quality while preserving the environment and showing social responsibility. The study, through a rigorous systematic literature review, discovered that Quality 5.0 is an attempt to address the constraints of Quality 4.0, putting an emphasis on industry and the use of modern technology, mostly in manufacturing processes.  The study developed a framework for Quality 5.0, which extends quality management practices by including an equally strong human and social dimension. This work emphasizes that quality management systems in the era of Industry 5.0 should extend beyond profit making and competitiveness for individual organisations but should seek to promote social responsibility, resilience and sustainability. This study is in line with the United Nations’ Concept for Sustainable Development Goals (SDGs).