Bangladesh faces certain challenges incorporating Industry 4.0, which integrates automation, Artificial Intelligence (AI), the Internet of Things (IoT) and Advanced Data Analytics. The study aims to investigate the major challenges employees face in industries in Bangladesh and as well as the challenges faced by the industries implementing Industry 4.0. This study also presents some strategic approaches that company can implement to support employees in adopting Industry 4.0 environment. Data were collected from two major industries in Bangladesh. The major challenges were determined, then by further research 17 criterion were selected and analyzed by industry experts. Some strategies were found out from Systematic Literature Review.  IFS-TOPSIS and IFS-VIKOR methods were used to rank the final strategies. By identifying Spearman’s Rank Correlation Co-efficient finally top three strategies were determined which are practical, feasible, accessible to cope up with Industry 4.0 environment for both the employees and industries. This research provides actionable insights that prioritize continuous learning environment in organizations and a framework for upskilling the employees from the very beginning of their career.