This research's goal is to list and rate the variables that affect how well Micro, Small, and Medium-Sized Enterprises (MSME) function. The Total Interpretive Structural Modeling (TISM) technique determines the interconnectedness, relative importance, and relationships between various components. Analyzing these factors' dependencies and driving forces is another key component of the work. The findings revealed that organisational reform, entrepreneurial spirit, and government backing are the key motivators. MSMEs should concentrate on these elements to enhance their performance. Additionally, by reforming MSMEs' businesses, this strategy will increase their profitability and resilience.