The most life-threatening infectious disease the world has been fighting is SARS–CoV–2. The outbreak of this virus has affected so many day–to–day activities of people and businesses. Almost all businesses in India have been impacted by the lockdown and restrictions on connectivity to cities and towns. Moreover, many operations of the business have faced adverse consequences, which have led to the closure of a few businesses. One of the industries that was affected during the COVID outbreak was the blood bank. This study aims to assess the level of risk in the blood bank operations during COVID–19. The enablers, criteria, and attributes that facilitate the risk in blood bank operations were identified and evaluated using the multi-grade fizzy technique. The results stated that low risk was observed in the blood bank operation during COVID-19 and also that stayed the same during the emergence of any other infectious diseases. The final risk index average is 4.49, which confirms that it is low risk. An important performance analysis was performed to identify the attributes that contribute to higher risk in blood bank operations.