Occupational Health and Safety (OH&S) is an inseparable part of the labor and human resource system. Not only in industry but also educational institutions, everyone needs an OH&S guarantee. One particular place that has many risks and dangers in educational institutions is the laboratory. In the Engineering Faculty of Diponegoro University, there are sixty-two laboratories spread across twelve departments. This study aimed to identify the potential hazards that occur, determine the highest risk, and then design any improvements needed. This study applied the Hazard Identification Risk Assessment and Risk Control (HIRARC) framework. From the identification results, there were nine highest risks found in the Production Systems Laboratory, Microbiology Laboratory, Thermofluidic Laboratory, Electrical Energy Conversion, Power Systems Laboratory, and one non-routine activity with a risk rating ranging from 240-300 (200-400 = high risk, >400 = very high risk). Proposals for improvements were made based on five hierarchies of control, i.e., elimination, substitution, engineering control, administrative control, and personal protective equipment. Among the proposed solutions, there were also standard operating procedures and work permit forms to ensure the safety and health of each activity in the laboratories.