Industry 4.0 is already a reality in the industrial environment, even though it is not fully applied. The objective of this study is to raise the necessary requirements for the implementation process of Industry 4.0 in the context of heavy automotive manufacture. For this, the study was developed through a literature review on the subject Industry 4.0, a survey of the requirements of the heavy automotive industry and its prioritization, based on the relationship with technologies associated to Industry 4.0, using an approach adapted from the Quality Function Deployment (QFD) tool. The manufacturing requirements were validated with specialists from the automotive industry who also contributed to their prioritization regarding their degree of importance. The results show that some technologies of Industry 4.0 presented a much higher degree of prioritization related to the others, being mandatory for a manufacturing project. Thus, the present work can contribute to practitioners unfolding the principles of Industry 4.0 in manufacturing requirements, which can be used in the design of new heavy automotive assembly lines and, in addition, the findings contribute to the literature on Industry 4.0 filling extant theoretical gaps.