Surgical patient safety is a global issue that is currently widely reported patient demands for medical errors that occur in patients. The nurse is an important part in carrying out surgical patient safety because as part of the team in the surgical room. The purpose of this research is to analyze the application of surgical patient safety in hospital. The research design used was an analytic correlation with the cross sectional approach with the sample of nurses of Surgical Room of RS "X" and "Y" in City "A" as many as 48 people with total sampling technique. Data were collected using questionnaire and observation checklist and then data were analyzed using Spearman Rho. There was a significant positive correlation between age, education level, work experience, knowledge, attitude, work culture and motivation with the application of surgical patient safety by the nurse. While the gender factor has no correlation with surgical patient safety by nurses. Implementation of surgical patient safety in addition to individual factors there is several other factors that play a role such as age, education level, work experience, knowledge, attitude, work culture and motivation. Therefore, its application needs to be improved with the formulation of special policies on documenting surgical patient safety to improve the quality of service.