The climate in a hospital’s operating theatre in terms of temperature, air flow and humidity affects medical personnel’s working conditions and the healing process for patients. Evaporative cooling technology is a sustainable option whose latent load can be handled desiccant dehumidification. The combination of a liquid desiccant and electro-hydrodynamic techniques to produce small droplets with increased surface contact for humidity reduction is commendable. Accordingly, this study is centered on developing Computational Fluid Dynamics simulations in ANSYS FLUENT for electrospray modelling. A numerical code is developed to simultaneously solve the coupled electrohydrodynamic and electrostatic equations and determine the shape of cone jet as an effect of the applied electric field for a glycerol electrospray in an air dehumidification system. The Volume of Fluid model of CFD FLUENT and Melcher-Taylor leaky dielectric model was established. The CFD model developed does not include a droplet break-up and the dynamics of droplet evaporation.