The decision of facility location selection for a manufacturing organization affects for a long term on business profitability. This decision is based on many conflicting factors of tangible and intangible nature. Location decision once taken is very difficult to be reversed for the organizations. Therefore, facility location selection is predominant strategic decision domain for the manufacturing organizations. Such complex decisions can be made by application of multi-criteria decision-making (MCDM) methods. Various MCDM methods have previously been used to solve such problems. In this paper, a real time case study is presented for selection of the most suitable plant location site for a private sugar production unit using desirability function approach. This approach is based on a concept of determining global attractiveness of an alternative in the form of overall desirability. The estimated response models for different decision criteria are converted into individual desirability functions using exponential transformation process, that are further aggregated into a composite function. The results derived by using desirability function approach are then confirmed by application of utility concept method, which exactly corroborate with each other. Additionally, single dimensional weight sensitivity analysis proves robustness of the results generated using this approach.