BDPA research in humanitarian supply chain operations has gained popularity for its ability to manage disaster risks. BDPA approach not only aims to predict future events, but also concentrates on current events and further prepare for the future events. However, review of prior studies shows this area is highly diverse and fragmented. Further, BDPA driven approach in HSC operations is complicated due to presence of multiple barriers, whose interrelationships are yet to be documented for purpose of enhancing existing knowledge base. The gaps in existing literature motivated to pursue the current study and aim to identify the leading barriers and further categorize them and finally develop the contextual interrelationships using popular Fuzzy Total Interpretive Structural Modeling approach. Fuzzy TISM is a well expressed mental model interpreting both the nodes (indicating ‘what’) and links (indicating ‘how’ and ‘why’) which serves as the basis for theory building process. The TISM model shows that the fifteen barriers have achieved eight levels and decision makers must aim to remove the bottom level barriers for achieving sustainability in humanitarian supply chain operations.