A survey of literature regarding ERP system supports for management decision-making in organizations revealed contrary views. According to some researchers, ERP systems only integrate business processes and functions and bring about efficiency in organizations. From various literature reviews, it is clear that there is an ambiguity in ERP systems effectiveness to support management decision-making.  Research on ERP systems effectiveness impact on management decision-making in HEIs is rare. Therefore, this study seeks to investigate this phenomenon by adopting a framework of Peters and Aggrey to evaluate the influence of ERP systems effectiveness on management decision-making in HEIs. Using relevant theoretical foundations, a research model was developed to test five relevant hypotheses. Using quantitative research, data were collected from 150 administrators and managers of three case study universities in Ghana. Data was analyzed using PLS-SEM and the findings revealed that ERP systems effectiveness based on these perspectives (financial, learning and growth, customer/stakeholder and system quality) influence more significantly on management decision–making in HEIs unlike Internal business process perspective. The findings backed the idea that, ERP systems supports and improve management decision-making. The findings also support the research model proposed.