Handicraft occupation is a strenuous job, often performed in poor work settings. Working in such conditions for a long period of time may lead to musculoskeletal pain in different body regions. The study aimed to evaluate the prevalence of lower back pain and their associated work-related psychosocial risk factors among the male handicraft workers in India. A self-reported questionnaire study was conducted among 286 male handicraft workers, including gemstone cutters, metalcraft workers, and miniature painters. The lower back pain was found to be the most prevalent (75.18%) and severe work-related health problem in this occupational group. Work-related psychosocial factors such as high job demand and low job control showed a significant association with the development of lower back pain. The findings suggested that despite the substantial impact of the physical work with respect to the etiology of musculoskeletal pain, researchers should expand their focus to work-related psychosocial issues. Preventive intervention strategies ensuring ergonomic workload and flexibility at the workplace of handicraft workers are highly recommended.