Tanah Papua is the homeland of peace, harmony, and tolerance. YAPIS is the reflection of this situation. Higher education is a part of human resource development. However, there are always obstacles where the distance between Jakarta and Jayapura is wide. Meanwhile, natural conditions do not allow for the simultaneous dissemination of information. This research was carried out with a qualitative design with a case study format. The research focuses on higher education institutions in Yapis Wamena. This study explores the existence of YAPIS and the role of universities in Papua. There are two research questions, namely how Papuan universities maintain institutions. Second, how YAPIS become an institution that can manage education with all the limited conditions.  This research shows that the existence of YAPIS becomes a catalysator for the existence of multi-multiculturalism. Furthermore, the YAPIS institution centered in Jayapura made it possible to establish branches throughout Papua. Human resource development is the reason for the establishment of the organization. although there are religious differences, but that is not an excuse not to provide opportunities for anyone to keep learning. This research findings explores the existence of YAPIS formulated education a means of educating human life as a national mandate. Furthermore, with the support of various parties, YAPIS has so far managed education from elementary schools to universities. In addition, the current university enjoy its second year after the institutional transformation of the college. Higher education development is carried out to provide wider opportunities and the opening of non-monodisciplinary department programs. Finally, this paper conclude that science and technology as a mean to serve the society, not the religion itself.