In present scenario manufacturing organizations are facing problem related to quality, cost, and customer satisfaction in the current market. To overcome such situation manufacturing companies are ready to adopt continues improvement (CI) techniques which keep them stable in fluctuation in demand as per market situation. Lean Six Sigma (LSS) is continues improvement methodology which helps to improve the bottom line result of company with use of their tools and techniques. The successful implementation of Lean Six Sigma approach provides significant improvement in key metrics but deficiency of proper implementation of LSS provides negative effect. To prevent such situation need to have knowledge about their failure factors. The study main objective is to assess the Lean Six Sigma critical failure factors (CFFs) for implementing their framework in manufacturing organizations. The leading LSS-CFFs for manufacturing organizations situated in India has been identified and selected through literature review and experts opinion. The model on LSS critical failure factors has been developed using ISM-MICMAC approach. The developed structured model will help LSS practitioners, consultants, researchers to anticipate the potential CFFs to implement LSS framework in their organization for continues improvement and achieve lead position in competitive market.