Street sweepers are known to experience high levels of musculoskeletal disorders (MSDs) due to the physically demanding nature of their work. This study aimed to identify the risk factors affecting work-related musculoskeletal disorders (WMSDs) among street sweepers in Quezon City, Philippines. The researchers investigated various demographic (age, gender, occupational seniority), individual-related (BMI, drinking habits, smoking habits), work-related (work duration, work posture, work tools), and environmental (heat exposure, noise exposure) factors. A total of 130 participants were included in the study, exceeding the required sample size of 123. Quantitative research methods were utilized, with data collected using the MSD Severity and Frequency Questionnaire (MSFQ) and a researcher-administered questionnaire. The Ovako Working Posture Assessment System (OWAS) was employed to assess working postures, while a weighing scale and measuring tape were used to record participants’ weight and height. Multiple Linear Regression was performed to examine the relationship between the prevalence of WMSDs and the identified risk factors. The results revealed that four factors—work duration, work tools, drinking habits, and smoking habits—were significantly associated with the prevalence of WMSDs. These findings highlight the importance of addressing these significant risk factors to improve the quality of life of street sweepers.