In the dynamic landscape of modern manufacturing, optimizing supply chain sustainability has emerged as a paramount concern for companies seeking to balance profitability with environmental and social responsibility. This multifaceted challenge involves processes, stakeholders, and resources required in sourcing, production, and distribution across global supply chains. As industries strive to reduce carbon footprints, minimize waste, and maintain ethical standards, the need for effective strategies to navigate these complexities becomes increasingly pressing. In this context, our analysis aims to explore and evaluate a range of strategies aimed at enhancing supply chain sustainability within the manufacturing sector. Through a comprehensive examination of criteria analyzed from the existing literature, we seek to prioritize strategic approaches as drivers of operational efficiency while promoting long-term sustainability across the supply chain ecosystem. To achieve this goal, we propose a Multi-Criteria Decision-Making (MCDM) procedure to identify the most effective strategies for enhancing supply chain sustainability, accounting for trade-offs under the considered criteria. Leveraging expert-based insights, our framework aims to represent a flexible procedure for different manufacturing contexts, empowering organizations to advancing sustainability goals. In the dynamic landscape of modern manufacturing, optimizing supply chain sustainability has emerged as a paramount concern for companies seeking to balance profitability with environmental and social responsibility. This multifaceted challenge involves processes, stakeholders, and resources required in sourcing, production, and distribution across global supply chains. As industries strive to reduce carbon footprints, minimize waste, and maintain ethical standards, the need for effective strategies to navigate these complexities becomes increasingly pressing. In this context, our analysis aims to explore and evaluate a range of strategies aimed at enhancing supply chain sustainability within the manufacturing sector. Through a comprehensive examination of criteria analyzed from the existing literature, we seek to prioritize strategic approaches as drivers of operational efficiency while promoting long-term sustainability across the supply chain ecosystem. To achieve this goal, we propose a Multi-Criteria Decision-Making (MCDM) procedure to identify the most effective strategies for enhancing supply chain sustainability, accounting for trade-offs under the considered criteria. Leveraging expert-based insights, our framework aims to represent a flexible procedure for different manufacturing contexts, empowering organizations to advancing sustainability goals.