This research set out to examine a variety of variables for a full determination of the effects of all factors pertaining to deposition techniques and interactions between nanoparticles and substrates on the hydrophobicity and wettability of surface materials. The hydrophilic and hydrophobic effects on the super-hydrophobic and self-cleaning properties of Calcium Oxide nanoparticles (CaOnp) were examined. The deposition was done on glass and silicone rubber (PDMS) substrates. The microstructure, contact angle hysteresis (CAH), and static contact angle (SCA) were all used to evaluate the characteristics. The results demonstrate that the hydrophobic CaO nanoparticles and PDMS substrate interact synergistically to produce more advantageous hierarchical topologies with lower surface energy. The results show that PDMS in combination with hydrophobic CaO nanoparticles as well as horizontal and vertical drying procedures both satisfy the two requirements for a self-cleaning surface and super-hydrophobic surface.