This study presents an integrated solution to the challenges in the global clothing industry, prioritizing worker well-being and environmental sustainability. Through an ergonomic framework, it aims to achieve sustainability and cost-effectiveness. The research employs established tools like RULA and REBA and diverse methods, including observations, interviews, and questionnaires, to quantitatively and qualitatively assess ergonomic risks. The study guides the clothing sector towards a more ethical, sustainable, and efficient production paradigm, bridging the gap between ergonomics, sustainability, and cost-effectiveness. It addresses the need for a conscientious transformation, ensuring economic growth aligns with workers' welfare and environmental responsibility.