The paper gives insights about carrying out maintenance activities in hazardous work environments by first identifying factors that affect the maintenance activities and then uses the Total Interpretive Structural Modelling (TISM) method to analyse the interrelationship between identified major factors that affect the mechanical maintenance activities in hazardous environment in process industries. The MICMAC analysis used to rank these factors. The identified key factors are effectiveness and robustness of safety department, tools and technology being used for the maintenance activities. This paper states that safety department plays an integral role in providing a safe environment for the working maintenance teams.