The purpose of this study was to examine the role of knowledge and satisfaction of nursing services through community responses to immunization coverage in the work area of the Public Health Centre (PHC) in Central Mamuju. The method used in this research is a survey method with a combination of quantitative approaches. The study population was parents or mothers of children under five in the working area of the health centre, totalling 290 populations. The number of samples in this study using the Slovin formula with a comprehensive selection of 168 pieces using non-probability sampling techniques, namely accidental sampling, determines the model based on chance using path analysis. The results showed that: 1) Knowledge has a significant and positive influence on the community response in the work environment. 2) Satisfaction of nursing services has a significant and positive influence on community response in the work area. 3) The community response has a significant and positive effect on immunization coverage. 4) The role of knowledge has a significant and positive effect on immunization coverage in the Work Area; 5) Satisfaction of nursing services significantly affect immunization coverage in the Work Area. 6) The role of knowledge has a positive and significant effect on immunization coverage through community responses. 7) Nursing service satisfaction has a positive and significant effect on immunization coverage through community response.