Startup business success stories, especially in the creative industry, currently dominate businesses in the world, including in Indonesia. Start-up businesses are expected to develop and master various lines of business, which change human civilization and habits, especially in the use of digital technology. This study aims to see how the implementation of quality management by startup businesses, the constraints and solutions carried out. The research was conducted on MSEs based on creative industries, especially food. The startup business studied is in the bootstrapping stage, where the business is still run by the nuclear family and there is no capital investment. The research method is a survey, on a startup business that is developing in West Java, Indonesia. The data shows that SMEs experience problems in the quality management system, especially looking for forms of quality planning and control, collaboration is still low both from upstream and downstream which results in low product and service quality. Start-up businesses will develop well if they use digital marketing as a marketing base and collaborate with suppliers and distributors who have reliability in product quality and distribution.