This paper presents cyber-security (CS) challenges in the wake of the Industry 4.0 (I4) age since, considering the high-level of technology employed in this new stage, a proper CS-I4 architecture model is demanded. This dependence for a complete CS system in the I4 forces organizations to create solutions that ensure cyber security effectively implemented and operating whenever is necessary. Real cases and concepts from the literature are summarized in the common challenges. This paper contributes with a thorough discussion on the adoption of the Industry 4.0 considering the threats in an entire process of information, communication, computing, or any data-related issue in an organization. Important steps to minimize risks related to cyber security can be utilized as a framework or best practice manual for early adopters of a CS-I4 system architecture.