As global competition between industries and countries intensifies, demand for processors to increase productivity, production and service quality continues to grow. This requires a versatile organization and the right tools to develop more efficient processes, reduce costs and increase productivity. The continuous development of global technology will affect the way customers behave, think and perceive value. Virtually all stages of change experienced by the manufacturing sector are modeled on human needs and growing customer demand. The manufacturing era is facing a new era of this ever-changing and challenging environment, often referred to as the Fourth Industrial Revolution. In the complex and changing business world, innovation and entrepreneurship have become key concepts for sustainable economic development. Economic, social and environmental sustainability are critical to organizational performance. This paper developed on the concept of previous research on Industry 4.0, entrepreneurial orientation, innovation and firm performance. It is hoped that this research will help to open a new window in the Industry 4.0 and entrepreneurial orientation research.