The purpose of this study is to increase the Overall Equipment Effectiveness (OEE) index in a Peruvian plastic packaging company through the implementation of Preventive Maintenance, Autonomous Maintenance, and SMED. The initial diagnosis showed an average OEE of 66.71%, a value below the 85% standard. To address this gap, Preventive Maintenance was introduced as a measure to reduce machine downtime, focusing exclusively on the molds to ensure proper condition, reliability, and reduction of mold-related failures. Subsequently, the SMED methodology was applied to optimize and standardize mold changeover activities, further minimizing production stoppages. Finally, Autonomous Maintenance was implemented to reduce defects caused by contamination in the injection machine components through routine cleaning, inspection, and basic operator-led maintenance. The proposal was validated through a pilot test and a simulation in Arena software, which demonstrated significant improvements, achieving a final OEE of 77%. The economic evaluation confirmed the project's feasibility, reporting a NPV of S/ 25,398, an IRR of 31%, and a recovery period of 2.5 years, demonstrating the investment’s profitability and sustainability. Overall, the implemented improvements resulted in more efficient and stable operational performance.