This case survey assessment contributes to the Workplace Ergonomic Risk Assessment (WERA) tool to review the ergonomic risk factors related to Musculoskeletal Disorder (MSD). This case study was conducted in the thread manufacturing industry in the southernmost part of Tamil Nadu. Within the legality trial, the connection between the individual WERA body part scores to the improvement of pain or inconvenience is factually critical for the wrist, shoulder, and back areas. It suggests that the WERA assessment will provide a good suggestion for a musculoskeletal issue, which may be recorded for pain, ache, or inconvenience to the significant employee. It is an observational technique to assess the work rapidly and identify the ergonomic risk factors associated with physical hazards. This work aims to reduce the ergonomic risk factor by introducing some recommendations to improve the workstation and reduce the employee’s discomfort. This research will increase the awareness of the ergonomic risk factor, which may occur in the thread manufacturing industry.