In today's disruptive business environment, organizations must constantly seek new methods to meet client needs, including offering environmentally friendly products and services.  Studies show that Industry 5.0 practices, particularly Quality 5.0, have the potential to transform processes and ensure sustainable and resilient quality practices while meeting customer demands.  However, the implementation of Quality 5.0 is unfamiliar, and its adoption trajectory is setting specific, with businesses in advanced economies responding better than those in developing nations like South Africa.  This study uses an online survey of 50 people selected using snowball sampling to discover factors that shape Quality 5.0 readiness in developing economies based on their distinct economic, infrastructure, skills, and socioeconomic characteristics.  The study used EFA to identify elements relating to sustain-ability, human-centeredness, responsible technology adoption, and resilience that, if ignored, could threaten the success and ethical responsibility of Quality 5.0. The study recommends ethical Quality and environmentally responsible 5.0 adoption following the empirical framework developed in this study to ensure that value is extracted from Industry 5.0 initiatives.