It has now become almost necessary to adopt digital transformation in humanitarian logistics with regard to disaster responses becoming more prominent and complex. There still lacks an understanding of the important factors involved in ensuring the implementation of Industry 5.0 among these areas. The main objective of this paper is to pinpoint as well as assess the core elements needed for Industry 5.0-based digital transformation of humanitarian logistics processes. A total of twenty experts representing various NGOs globally, United Nations bodies, government disaster management units, and humanitarian technology solution companies participated in the analysis. By using a set of properly identified factors and carrying out Best-Worst Method (BWM) analysis for importance evaluation and Decision-Making Trial and Evaluation Laboratory Method  (DEMATEL) to identify interactions among these factors, it was found that factors with highest influencer scores are strong analytical and data-driven decision-making capacities, committed leadership and donor support, effective information sharing across agencies, robust security and privacy practices, and a workforce capable of adopting new technologies. The causal network moreover emphasizes that analytical ability enhancement and interoperability of data among different organizations offer the utmost potential for facilitating digital transformation within the humanitarian sector. Lastly, this research offers an expert system Critical success factors (CSFs) model designed for humanitarian logistics under Industry 5.0 as well as an analytical BWM/DEMATEL solution including with proper recommendations for designing human-centric secure, and resilient humanitarian supply chain strategies.