Micromachining has experienced a vast growth and is forecasted to be growing in next few decades specially in the semiconductor, nuclear and aerospace industries. Although there are multiple techniques of micromachining such as laser micromachining, chemical erosion, wire electrical discharge machining, micro-milling etc., in this study micromachining by CNC milling is analyzed and experimented. Initially, a theoretical analysis is performed by using CAD-CAM integration process considering machining rate and surface roughness as outputs. Based on this theoretical analysis, a practical experiment is conducted to observe cutting tools life and surface finish of the part while machining micro-channels in an aerospace grade aluminum. Tool wear is observed by varying feed rates keeping other cutting parameters as constant. In general, higher machining rate is achieved by higher spindle speed and feed rate but an inconsistency is observed in practical machining that needs further verification. Surface finish is found to be better at higher spindle speed at lower feed rate. A comparison between theoretical analysis and practical experimentation is also illustrated in this article.