This study presents a systematic comparison of four triply periodic minimal surface (TPMS) structures—Gyroid, Diamond, Primitive, and I-WP—fabricated using stereolithography (SLA) for multifunctional engineering applications. Through comprehensive experimental evaluation of airflow resistivity and mechanical properties, we demonstrate how topological design governs critical performance trade-offs between fluid permeability and structural integrity. The specimens were characterized under controlled loading and flow conditions to assess stiffness, strength, and pressure drop behavior. Among the tested architectures, Diamond structures exhibit superior characteristics for applications requiring both efficient fluid flow and high load-bearing capacity due to their balanced curvature and robust nodal connectivity. Gyroid configurations show versatile and well-balanced multifunctional performance, making them suitable for systems that demand both mechanical stability and moderate permeability. In contrast, Primitive and I-WP structures display intermediate performance with distinct advantages for specialized applications such as acoustic damping or controlled ventilation. The results reveal that pore connectivity, wall thickness, and mean surface curvature critically influence airflow resistance, while structural hierarchy and periodic symmetry determine mechanical stability. These findings provide fundamental insights into structure–property relationships in TPMS lattices and establish practical guidelines for selecting optimal cellular architectures in thermal management systems, energy absorbers, and lightweight structural components. Overall, the study establishes a comprehensive framework for designing TPMS-based solutions that simultaneously optimize ventilation efficiency, energy dissipation, and mechanical performance in advanced engineering applications