Bus drivers are exposed to Work-Related Musculoskeletal Disorders (WMSDs), which have become a significant occupational health concern. Numerous risk factors contribute to the occurrence of WMSD. This study identified significant risk factors among 11 variables contributing to the prevalence of WMSD among provincial air-conditioned bus drivers in Metro Manila bus hubs. A total of 124 bus drivers participated in the study. Data were collected using various data instruments, and multiple linear regression was used to determine the correlation between the prevalence of WMSD and the independent variables. IBM SPSS Software and WarpPLS were utilized for analysis. The results found that age, BMI, work tenure, repetitive movements, work duration, vehicle ergonomics, and work posture significantly affect WMSD. The Rapid Entire Body Assessment also indicated that the average risk level for bus drivers falls under the medium risk category. WMSD among bus drivers was found to be the most common in the feet (45.97%), lower back (38.71%), and shoulders (28.23%).