Industry 4.0 provides a lot of changes to the development of technology and business. In this Industrial Age, business people are given a new opportunity to build their business using advanced technology. Thus there will be many benefits in the Industrial era and of course there will also be various problems and threats that can occur. Business forms related to Industry 4.0 can be such as Digital Marketing, E-Business, E-Commerce, and E-Marketing, while related software forms can be such as Industrial Control System (ICS), Supervisory Control And Data Acquisition (SCADA), and Artificial Intelligence (AI). Therefore, in doing business in the industry, it is necessary to apply the correct business ethics to avoid the destructive impacts that can occur. In this study, the Systematic Literature Review method was used to analyze how the industrial world supports business ethics and identify what threats, problems, and challenges can be faced in industry 4.0 by applying laws and provisions in business ethics. This research produces an analysis of business activities in E-business, ethical issues in E-Marketing and several challenges that can threaten business ethics in Industry 4.0.

Keywords:
Business Ethics, Industrial 4.0.