This paper presents a systematic literature review investigating the key applications of Artificial Intelligence (AI) and Blockchain technologies for enhancing the resilience of pharmaceutical supply chains (PSCs). Using the PRISMA methodology, a total of 139 relevant articles published between 2000 and 2025 were identified from Web of Science, ScienceDirect, and IEEE databases. The analysis reveals that AI is primarily applied in PSCs for demand forecasting, inventory optimization, anomaly detection, logistics planning, and drug development, enabling improved decision-making and operational efficiency. Blockchain applications, on the other hand, focus on cold chain monitoring, data sharing and transparency, smart contracts, and traceability, supporting secure, tamper-proof, and real-time information flow across the supply chain. By synthesizing these applications, this study highlights how the integration of AI and Blockchain can address key resilience challenges in PSCs, such as supply disruptions, counterfeit drugs, and inventory imbalances. The findings provide researchers and practitioners with a comprehensive overview of current technological applications, serving as a foundation for future development of resilient and technology-enabled pharmaceutical supply chains.