The cold chain pharmaceutical supply chain (CCPSC) plays a crucial role in maintaining the safety and integrity of temperature-sensitive pharmaceuticals such as vaccines and drugs. With growing emphasis on temperature control in the healthcare industry, digital technologies are being widely adopted in CCPSC due to their ability to enhance real-time monitoring, improve traceability, and increase transparency across the supply chain. This study aims to identify major digital technologies in the field of CCPSC and to identify trends and gaps of digital technology application in the identified literature. A systematic literature review was conducted using PRISMA guidelines to identify relevant articles, which were further analyzed to determine whether they presented implementable frameworks. These frameworks were then examined to understand the technologies used and their application across five functional areas: manufacturing, storage & inventory management, distribution, transportation, and monitoring & control. Technologies such as blockchain, IoT, RFID, and smart contracts were found to be widely used. The study also identified that digital technologies are predominantly used in monitoring & control, in stark contrast to manufacturing. By mapping technologies to specific functions, this study offers insights for academics and decision-makers and lays the groundwork for future research.