This research presents a comprehensive analysis of the adoption of Quick Response Code Indonesian Standard (QRIS) by Micro, Small, and Medium Enterprises (MSMEs) in Indonesia, with a focus on increasing sales and digital payment integration. The research also uses SWOT analysis enriched with the Technology-Organization-Environment (TOE) and Unified Theory of Acceptance and Use of Technology (UTAUT) theoretical frameworks to identify internal and external factors that influence adoption. Findings show that while QRIS offers significant advantages in transaction efficiency and financial inclusion, MSMEs face challenges such as low digital literacy and cultural preference towards cash transactions. A strategic framework is proposed, which details Strength-Opportunity (SO), Weakness-Opportunity (WO), Strength-Threat (ST), and Weakness-Threat (WT) strategies to guide MSMEs and stakeholders. The report also highlights the uniqueness of the Indonesian context and discusses the transferability of the framework to other emerging economies.