There are recent calls for research into understanding how manufacturing operations in Ghana can be improved, make them competitive and also increase the sector’s contribution to the economy. Against this background, this study explored the relationships between supply chain strategies, competitive priorities and organizational performance in the context of manufacturing operations in Ghana. To achieve the research objectives, a structured questionnaire was used to collect data from 230 manufacturing firms. The data collected was analyzed quantitively through Structural Equation Modelling (SEM), to establish the anticipated relationships. The study revealed that, supply chain strategies measured by efficiency and responsiveness, positively influence competitive priorities (cost, quality, speed, flexibility and dependability) and organizational performance measure by revenue and market share. Efficiency as a supply chain strategy was found to impact more on market share than revenue. Also, competitive priorities positively influenced revenue than market share. Cost as a competitive priority positively influence revenue than market share.  However, Supply chain strategies had higher impact on revenue and market share than competitive priorities on revenue and market share. In view of this, the study recommends that Ghanaian manufacturing firms should adopt the efficient supply chain strategy and also Cost as a competitive priority to be able to improve their organizational performance and stay competitive.