This study successfully integrated the 5S methodology and the PDCA cycle to significantly enhance productivity within the university department's storage room. By utilizing key performance indicators (KPIs) and conducting a thorough cause and effect analysis, the study achieves substantial improvements. Specifically, the time required to locate essential items like apparel, cleaning products, and tissues decreased by 25%, 19.12%, and 44.4%, respectively. The finding shows that disorganization and excess inventory as the primary causes of inefficiency. These issues led to wasted time spent searching for items in a cluttered environment, were ultimately impacting overall productivity. This study offers a practical, long-term solution to address storage room inefficiencies by demonstrating the effective application of 5S, PDCA, and cause and effect analysis.