Human Factors and Ergonomics (HF/E) is increasingly recognized for its potential to enhance creative performance across various organizational contexts, including small and medium-sized enterprises and large corporations. This study aims to determine how HF/E dimensions—organizational, physical, cognitive, and environmental—support and enhance innovative capacity across creative and non-creative sectors. Through a systematic content analysis of 219 articles published between 2020 and 2024, we explore the breadth of ergonomic interventions and their interactions with creative thinking. Methodologically, a thorough screening process was conducted to extract relevant themes, classify HF/E elements, and identify patterns across industry settings. The data were then organized across HF/E dimensions, and each category was evaluated based on its impact on collaborative culture, user interface design, risk reduction, and idea generation. The results reveal that organizational ergonomics often foster leadership commitment and employee empowerment, physical interventions reduce tension while enhancing creative potential, and cognitive ergonomics enhance mental clarity for innovation. Environmental factors like layout and lighting further facilitate collaborative ideation, while combined approaches consistently produce the most substantial results. Integrated HF/E applications significantly improve creative performance, although the impact varies by industry and type of organization. Constrained by limited resources, SMEs tend to focus on cost-effective ergonomic improvements, while large companies leverage sophisticated HF/E strategies. These findings underscore the importance of integrating HF/E holistically to sustain creativity and productivity. Overall, this study highlights how tailored ergonomic strategies can improve employee well-being and innovative outcomes, suggesting that HF/E is viewed as a fundamental pillar in future organizational development programs.