The substantial funding in Enterprise Resource Planning (ERP) systems by tertiary Institutions must be assessed based on their productivity of their implementation. With the growing acquisition and execution of ERPs in HEIs over the past decade, this study utilizes the investigative framework of Peters and Aggrey (BSC and ISO 25010) to assess the effectiveness of ERPs in Ghanaian tertiary education. The aim of this paper is to identify the key determinants for assessing the performance of ERPs in Ghanaian tertiary education using the adopted analytic framework. Based on the literature and studies reviewed, no existing research has established the significant factors for assessing ERP system effectiveness in Ghanaian higher education. A combined-method research approach was utilized, with quantitative records gathered from 173 managers and administrators across three case study universities in Ghana (University_of_Ghana, University_of_Cape_Coast, and Kwame_Nkrumah_University_of_Science_and_Technology), all of which have executed ERPs for two or more years. Additionally, six managers from these tertiary institutions were interrogated for the qualitative investigation. Data were investigated through partial_least_squares structural_equation_modeling (PLS-SEM) and inductive=thematic=analysis. The results of the research indicated that the financial=perspective, customer/stakeholder=perspective, learning=growth=perspective, and system=quality=perspective are significantly or positively associated with the effectiveness of ERP systems in Ghanaian higher education. Interestingly, the findings revealed that the internal=business=process=perspective had no important impact on the effectiveness of ERPs in HEIs. Works on the assessment of ERP system effectiveness in Ghanaian tertiary institutions are scarce. A practical implication of these findings suggests that when assessing ERPs performance in tertiary education, particularly in the Ghanaian context, the financial, learning & growth, system quality, and customer/stakeholder perspectives play crucial roles that must not be overlooked by the evaluation team. Therefore, this study has successfully evaluated the performance of ERPs in Ghanaian tertiary institutions and demonstrated the effectiveness of the proposed research framework.