Blockchain is one of the emerging trends that could transform Supply Chains making it robust and secure. Effective management of Supply Chains is crucial in industries such as finance, healthcare, food, and logistics not just at a time of pandemic but also for routine operations. Supply chain processes are potential sources of competitive advantage for firms in a highly competitive market. Blockchain in Supply chains will be a disruptive innovation that could significantly transform Supply Chains. Implementing blockchain could reduce costs, reduce administrative and logistical errors, speed up the processes and make the entire supply chain very dynamic and streamlined to all stakeholders. This paper aims to understand how various firms from different industries have effectively implemented blockchain technologies in their supply chain processes to improve transparency, integrity, and accessibility. Information asymmetry is quite common in supply chains and is a serious issue in current times especially during an ongoing pandemic. Blockchain could also aid in minimizing information asymmetry at different stages of the supply chain. This paper using a case study approach aims to highlight how different industries strategically use blockchain to their competitive advantage.