In Oman, particularly in Muscat, efficient medical supply warehousing is crucial for enhancing public health resilience. Addressing this need is essential to meet the growing demands of the healthcare sector. An optimized warehouse layout supports timely distribution, reduces operational costs, and maximizes storage utilization while promoting sustainability by decreasing resource consumption and emissions. This study aims to design a strategic and effective warehouse model, highlighting the importance of optimized warehousing in strengthening the flow of warehouse operations. The study compares three storage policies to determine the most suitable option for the case study. The primary factor in comparing these policies is the total number of pallets required, which serves as a measure of the space needed for medicine storage. For the randomized policy, the analysis concluded that 110,115 pallets were required. This result was applied in the class-based dedicated policy, where the warehouse was divided into three categories to assess space needed for each item type. Finally, the total space required for the dedicated storage policy was found to be 133,299 pallets. In the layout design phase, three alternative configurations were developed to simulate suitable scenarios for warehouse operations. Each alternative was compared based on a key factor: minimizing the total travel distance required to complete essential warehouse tasks, such as receiving and placing orders in storage. Alternative 1 achieved a minimized travel distance of 18,850,896 meters from storage areas to docks, selected for its effectiveness in reducing both time and effort. The final design includes a detailed block layout and 3D sketches to visualize the setup