This paper explores the concept of Operational Excellence and its achievement through the implementation of Lean Six Sigma (LSS). We define Operational Excellence and LSS, and delve into the DMAIC phases of LSS, which are the cornerstone of this methodology. We also identify and discuss various types of wastes prevalent in different sectors, highlighting the need for LSS implementation. The paper presents a few case studies that demonstrate the successful application of the DMAIC framework in different contexts. Additionally, we outline essential tools for implementing LSS and discuss critical failure factors that organizations should be aware of. Finally, we conclude by emphasizing the significance of LSS in achieving Operational Excellence and enhancing organizational performance.