The textile and apparel industry significantly impacts the global economy, especially in regions like Latin America and Peru, where small and medium-sized enterprises (SMEs) are prominent. These SMEs drive economic growth and provide jobs but face production challenges, particularly related to On-Time In-Full (OTIF) fulfillment due to inventory management deficiencies. Common issues include stock-outs of raw materials and delays in material supply, often due to poor supply chain management and disorganized inventory control systems. This research proposed a Lean Production Model integrating 5S, Economic Order Quantity (EOQ), and Material Requirements Planning (MRP) to address these challenges. The model aimed to streamline processes, optimize inventory management, and improve overall production efficiency. Key results showed a significant improvement in the OTIF index from 52.37% to 85%, a reduction in defective materials by 15%, and a decrease in search time by 20%. The implementation also reduced product contamination incidents by 10% and improved inventory levels, ensuring a minimum inventory of 285 cones each month. This study provided a comprehensive framework for process improvement in textile SMEs, emphasizing the importance of adopting Lean principles to enhance operational performance and competitiveness. Further research should explore integrating these methodologies in different contexts to continue improving the efficiency and sustainability of textile SMEs.