Mobile Learning Application (MLA) is an accommodating technology to instructors wherein their lessons and other usable features in teaching can be done and applied online. In the Philippines, the application of this technology seems to be still lacking, most especially among high school students in government-owned institutions. At present, the subject of this study uses an online application to help senior high school students focusing on accounting and business management to review and understand their lessons further. Based from the SUS survey, the current mobile application utilized has a computed mean score of 55.25%, which is below the 68% marginal average scale for a usable system. This study aims to identify the statistically-significant variables affecting the usability of a mobile learning application to enhance its efficiency and effectiveness in improving the user experience of the students. Recommendations in this study uses the significant variables in creating an ergonomically-designed mobile learning application that will improve its user effectiveness and its usability to be utilized as a student-centered academic portal.