In the contemporary business landscape, marked by intense competition, organizations continually seek innovative strategies to elevate efficiency and achieve heightened productivity. This quantitative research investigates the influence of cross-functional information sharing facilitated by Enterprise Resource Planning (ERP) system integration on productivity within a typical small-medium pharmaceutical company. Grounded in the foundational framework of DeLone and McLean (1992), the study examines the intricate relationships between ERP system integration, cross-functional information sharing, and resultant productivity improvements. Data was primarily sourced from a survey administered across various departments within DAS Pharma Plc, to help the research explore the extent of ERP system integration, cross-functional information-sharing practices, and perceived productivity enhancements within an organisation. The research findings hold significant implications small-medium Pharma companies and the broader pharmaceutical industry, emphasizing the role of ERP systems in fostering effective communication and collaboration across organizational functions. The research also contributes empirically to both theoretical and practical knowledge as it attempts to explain the nuanced relationships between ERP system integration, cross-functional information sharing, and productivity enhancement within DAS Pharma Plc. The insights gained could offer strategic guidance for optimizing operations and attaining sustainable competitive advantage in the dynamic small-medium pharmaceutical sector.