This research investigates disruptive innovation reshaping supply chains for the burgeoning space economy, focusing on advanced manufacturing capabilities. Leveraging the 2022 European Manufacturing Survey data, cross-lagged analysis explores relationships between technological advancements (automation, robotics, additive manufacturing), organizational concepts, and relocation strategies for enabling resilient manufacturing. Key competitive standards like novel business models are evaluated against the 2019-2021 economic and environmental turbulence. The study examines integral strategies that shaped manufacturers' resilience, including innovation outsourcing and sustainable Industry 4.0 adoption. Utilizing partial structural equation modeling (SEM) and PRISMA analysis, time-series data from 2019-2021 assesses core metrics, supply chain structures, and human resources strategies. Findings emphasize innovative business models aligning production-consumption systems with the circular economy. Organizational restructuring for digitalization and integration of enabling technologies like smart factories are highlighted. Strategic imperatives surrounding workforce upskilling, cybersecurity frameworks, product-service models, and coherent digital manufacturing integration are underscored. This multidimensional analysis guides sustainable, intelligent transformation of global manufacturing ecosystems for the space economy.